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Does acne get worse before it gets better on isotretinoin? Some people notice that their acne initially gets worse after starting isotretinoin therapy. The number of acne lesions usually does not increase, but the lesions may become redder or more painful. This is normal, lasts only a short while, and is not a reason to stop using isotretinoin.
How much Accutane should I take in total? The recommended dosage range for Accutane is 0.5 to 1.0 mg/kg/day given in two divided doses with food for 15 to 20 weeks. In studies comparing 0.1, 0.5, and 1.0 mg/kg/day,8 it was found that all dosages provided initial clearing of disease, but there was a greater need for retreatment with the lower dosages.
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