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Can methotrexate work immediately? How long will methotrexate take to start working ? It's not immediate. Many RA patients will start to experience an improvement in symptoms after six to eight weeks on methotrexate, but it can take up to six months before you would reach the full benefits of taking the drug.
Is Methotrexate safe long term? Severe adverse effects are more common with the higher doses of methotrexate used for antineoplastic indications. However, hematological toxicity is reported to occur in up to 3% of patients treated with long - term, low-dose methotrexate for RA and other autoimmune disorders (Lim, Gaffney, & Scott, 2005).
Do the side effects of methotrexate ever go away? Methotrexate can cause mouth ulcers in a few patients, in the beginning of treatment. This should go away with time. Another possible side effect is nausea and vomiting. This blood work will also include a complete blood count (CBC) since methotrexate can also cause a decrease in blood counts.
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